 經歷︰ |
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高雄醫學大學 |
生物醫學及創新育成中心 |
主任 |
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高雄醫學大學 |
醫學遺傳研究所 |
教授 |
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高雄醫學大學 |
醫學系實驗診斷科 |
教授 |
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高雄醫學大學 |
基因體醫學研究中心 |
主任 |
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高雄醫學院 |
醫學系實驗診斷科 |
副教授 |
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高雄醫學院 |
醫學系實驗診斷科 |
講師 |
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印第安納州立大學 |
基因體醫學研究中心 |
研究員 |
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高雄醫學院 |
醫學系實驗診斷科 |
助教 |
學歷︰ |
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高雄醫學院 |
醫學研究所 |
博士 |
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高雄醫學院 |
醫學技術系 |
學士 |
專長︰ |
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1.分子生物學 |
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2.臨床微生物 |
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3.臨床醫學 |
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著作︰
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1 |
Hsieh MC, Tien KJ, Chang
SJ, Lo CS, Hsin SC, Hsiao JY, Hsu SC, Liang HT,
Chen HC, Shin SJ, Lin SR. 2007. Cholesteryl
ester transfer protein B1B1 genotype as a
predictor of coronary artery disease in
Taiwanese with type 2 diabetes mellitus.
Metabolism (in press) (correspond) (SCI). |
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2 |
Chong IW, Sheu CC, Chang MY, Wang YH, Wang CY,
Hwang JJ, Huang MS , Lin SR. 2006. Detection of
Activated K-ras in Non-Small Cell Lung Cancer by
Membrane Array: A Comparison with Direct
Sequencing. Oncology Reports (in press)
(correspond) (SCI).
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3 |
Tsai JR, Chong IW, Chen YH, Yang MJ, Sheu CC,
Chang HC, Hwang JJ, Hung JY, Lin
SR.2006.Differential Expression Profile of MAGE
Family in Non-Small Cell Lung Cancer. Lung
Cancer. (in press) (correspond) (SCI)
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4 |
Wang JY, Lin SR, Wu DC, Lu CY, Yu FJ, Hsieh JS,
Cheng TL, Koay LB, Uen YH. 2006. Multiple
Molecular Markers as Predictors of Colorectal
Cancer in Patients with Normal Peri-operative
Serum CEA Levels. Clin. Cancer Res. (in press)
(SCI).
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5 |
Chen CC, Chang TW, Chen FM, Hou MF, Hung SY,
Chong IW, Lee SC, Zhou TH, Lin SR.,Combination
of multiple mRNA markers PTTG1, Survivin,
UbcH10, and TK1 in diagnosis of Taiwanese
patients with breast cancer by membrane array.
Oncology (in press) (correspond) (SCI)
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6 |
Wang JY, wang YS, Lao SW, Lu CY, Kuo CH, Hu HM,
Chong IW, Huang SY, Zhou TH, Cheng TL, Lin SR.
2006. The correlation between the transforming
capacity of colon polyps and activated k-ras
oncogene . Oncology Reports (in press)
(correspond) (SCI).
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7 |
Chong IW, Chang MY, Chang HC, Yu YP, Sheu CC,
Tsai JR, Hung JY, Chou SH, Tsai MS, Hwang JJ,
Lin SR. 2006. Great potential of a panel of
multiple hMTH1, SPD, ITGA11 and COL11A1 marker
for diagnosis of Taiwanese patients with NSCLC.
Oncology Reports 16(5):981~8. (correspond)
(SCI).
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8 |
Sheu CC, Chang MY, Chang HC, Tsai JR, Lin SR,
Chang SJ, Hwang JJ, Huang MS, Chong IW.2006.
Combined Detection of CEA, CK-19 and c-met mRNAs
in Peripheral Blood: a Highly Sensitive Panel
for Potential Molecular Diagnosis of Non-Small
Cell Lung Cancer. Oncology 29;70(3):203-211
(SCI)
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9 |
Sheu CC, Yu YP, Tsai JR, Chang MY, Lin SR, Hwang
JJ ,Chong IW*.2006. Development of a Membrane
Array-Based Multimarker Assay for Detection of
Circulating Cancer Cells in Patients with
Non-Small Cell Lung Cancer. Int J Cancer 119(6):
1419-1426 (SCI).
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10 |
Tsai JR, Chong IW*, Chen CC, Lin SR, Sheu CC,
Hwang JJ. 2006. Mitogen-activated protein kinase
pathway was significantly activated in human
bronchial epithelial cells by nicotine . DNA and
Cell Biol 25(5) 312~322.(SCI).
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11 |
Wang JY,Yeh CH, Chen YF,Wu CH, Hsieh JS, Huang
TJ, Huang SY, Lin SR. 2006. Development and
evaluation of a colorimetric membrane-array
method for the detection of circulating tumor
cells in the peripheral blood of Taiwanese
patients with colorectal cancer. Int J Mol Med
17(5): 737-648 (correspond) (SCI).
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12 |
Wu CH, Lin SR, Yu FJ, Wu DC, Pan YS, Hsieh JS,
Huang SY, Wang JY. 2006. Development of a
High-Throughput Membrane-Array Method for
Molecular Diagnosis of Circulating Tumor Cells
in Patients with Gastric Cancers. Int J Cancer
119(2):373-9.
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13 |
Chung FY, Lin SR, Lu CY, Yeh CS, Chen FM, Hsieh
JS, Huang TJ, Wang JY. 2006. Sarco/Endoplasmic
reticulum calcium ATPase 2 expression as a tumor
marker in colorectal cancer. Am J Surg Pathol.
30(8):969-74 (SCI).
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14 |
Uen YH, Lin SR, Wu CH, Hsieh JS,
Lu CY, Yu FJ, Hung TJ, Wang JY. 2005.Clinical
significance of MUC1 and c-Met RT-PCR detection
of circulating tumor cells in patient with
gastric carcinoma. (Clinica Chimica acta
367(1-2):55-61 (SCI).
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15 |
Yeh CH, Wang JY, Wu CH, Chong IW, Chung FY, Wang
YH, YU YP, Lin SR.. 2005.
Molecular detection of patients with colorectal
cancer by using membrane array with a multiple
mRNA marker panel. Int J Oncology 28 (2):
411~420. (correspond) (SCI).
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16 |
Wang JY; Wu CH; Lu CY; Hsieh JS; Wu DC;
Cheng TL; Huang TJ; Huang SY; Lin SR.2005.
Molecular Detection of Circulating Tumor Cells
in the Peripheral Blood of Patients with
Colorectal Cancer Using RT-PCR: Significance in
the Prediction of Postoperative Metastasis.
WJS 30: 1-7 (correspond) (SCI).
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17 |
Wu CH, Lin SR, Chen FM, Lu CY, Yu FJ, Cheng TL,
Huang TJ, Huang SY , Wang JY. 2006. Molecular
detection of disseminated tumor cells in the
peripheral blood of patients with gastric
cancer: evaluation of their prognostic
significance. Disease Markers 22(3):103-9 (SCI)
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18 |
Chen CC, Hou MF, Wang JY, Chang TW, Lai
DY, Chen YF, Hung SY, Lin SR.
2005. Simultaneous Detection of multiple mRNA
Markers CK19, CEA, c-Met, Her2/neu and hMAM with
Membrane Array, An Innovative Technique with A
Great Potential for Breast Cancer
Diagnosis.2005.Cancer letters 240(2): 279-88
(correspond) (SCI)
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19 |
Hsien JS, Lin SR, Chang MY, Chen
FM, Lu CY, Huang YS, Huang CJ, Wang JY.2005.
APC,K-ras and P53 gene mutation in colorectal
cancer patients: Correlation to
clinicopathologic features and postoperative
surveillance. The American Surgeon 71(4):
336-343.
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20 |
Yeh CS, Wang JY, Cheng TL, Juan CH,
Wu CH, Lin SR. 2005.Fatty acid
metabolism pathway play an important role in
carcinogenesis of human colorectal cancers by
Microarray-Bioinformatics analysis. Cancer
letters (in press) (correspond) (SCI)
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21 |
Wu CH, Lin SR, Chen FM, Lu CY, Yu
FJ, Cheng TL, Huang TJ, Huang SY , Wang JY.
2005. Molecular detection of disseminated tumor
cells in the peripheral blood of patients with
gastric cancer: evaluation of their prognostic
significance. Disease Marker 21:1-7 (SCI)
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22 |
Wang JY, Yeh CS , Tzou WS, Hsieh JS, Chen FM, Lu
CY, Cheng TL, Huang TJ, FM, Lin SR.
2005. Analysis of progressively
overexpressed genes in tumorigenesis of human
colorectal cancers using cDNA microarray.
Oncology Reports 14: 65-72. (correspond) (SCI).
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23 |
Wang JY, Hsieh JS , Chang MY, Huang TJ, FM,Cheng
TL, Huang YS, Lin SR. 2005. The
Differentially mutational spectra of the APC, K-ras
and p53 genes in sporadic colorectal cancers
from Taiwanese patients. Hepato-Gastroenterology
(in press) (correspond) (SCI)
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24 |
Chen YF , Wang JY
,Wu CH , Chen FM,
Cheng TL , Chang MY
, Lin SR.2005.
Detection the circulating cancer cells with K-ras
oncogene by gene chips. Cancer letters 229:
115-122 (correspond) (SCI)
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25 |
Chang MY, Chong IW, Chen FM, Wang JY, Cheng TL,
Cheng YJ, Sheu CC, Hung SY, Yang MC, Lin
SR. 2005. High frequency of frameshift
mutation on p53 gene in Taiwanese with Non small
cell Lung cancer. Cancer letters 222:195~204.
(correspond) (SCI)
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26 |
Wang JY, Lin SR, Lu CY, Chen CC,
Wu DC, Chai CY, Chen FM, Hsieh JS, Huang TJ.
2005. Gastric cancer cell detection in
peritoneal lavage: RT-PCR for carcinoembryonic
antigen transcripts versus the combined cytology
with peritoneal carcinoembryonic antigen levels.
Cancer letters (in press)
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27 |
Chen FM , Hou MF, Chang MY, Wang JY,
Hsieh JS, Ou-yang F, Huang TJ, Lin
SR. 2005 . High frequency of somatic
missense mutation of BRCA2 in
female breast cancer from Taiwan. Cancer
letters220: 177~184. (correspond)(SCI)
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28 |
Chen YF, Shin SJ, Lin SR. 2005.
Ets1 was significantly activated by ERK1/2 in
mutant K-ras stably transfected human
adrenocortical cells. DNA & Cell Biology 24(2):
126-132. (correspond)(SCI)
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29 |
Chye SM, Lin SR, Chen YL, Chung
LY, Yen CM.
(2004) Immuno-PCR for Detection of Antigen to
Angiostrongylus cantonensis Circulating
Fifth- Stage Worm. Clinical chemistry 50:
151-57.
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30 |
Hsieh JS, Wang JY*, Lin SR, Hsieh
TJ, Huang TJ. 2004; Spontaneous portosystemic
shunt fails to protect hemorrhage from oesophago-gastric
varices. World J Surg 28:23-28. (SCI).
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31 |
Wang JY, Hsieh JS , Chang MY, Huang TJ, FM,Cheng
TL, , Ketil. Alexandersen, , Huang YS, Tzou
WS,Chen , Lin SR. 2004, Molecular
Detection of the APC, K-ras, and p53 Mutations
in the Serum of Colorectal Cancer Patients as
Circulating Biomarkers. World J Surg 28(7)
721-726. (correspond)(SCI)
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32 |
Wang JY, Tzou WS, Hsieh JS, Wu CH,
Huang TJ, Huang YS, Chen CPD, Huang
KF, Chung YS, Lin SR.
2004.Alterations of APC, c-met, and p53 Genes in
Tumor Tissue and Serum of Patients with Gastric
Cancers. J Surg Res 120:242-248 (correspond)(SCI)
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33 |
Chen FM,Hou MF,Wang JY,Chen TC, Chen David CP,
Huang SU, Chung YS, Lin SR.2004
High frequency of G/C transversion on p53 gene
alterations in breast cancers from Taiwan.
Cancer letters 207:59-67(correspond)(SCI)
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34 |
Lai CL, Tai CT, Lin SR, Lin RT,
Yang YH, Liu CK. 2003. Apolipoprotein E in
Taiwan Chinese Patients with Dementia. Dementia
16: 208-211(SCI).
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35 |
Chen YF, Chiu HH, Wu CH, Wang JY, Chen FM, Tzou
WH, Shin SJ, Lin SR. 2003.
Retinoblastoma protein (pRB) was significantly
phosphorylated through Ras-to –MAPK pathway in
mutant K-ras stably transfected human
adrenocortical cells. DNA Cell Biol 22(10):
657~664 (correspond)(SCI).
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36 |
Wang J Y, Hsieh JS, Chen FM, Yeh CS, Huang TJ,
Lin SR.2003. High Frequency of
activated K-ras Codon 15 Mutants in Colorectal
Carcinomas from Taiwanese Patients. Int J Cancer
107(10): 387~393 (correspond)(SCI)
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37 |
Hsieh JS, Wang JY, Lin SR, Lian
ST, Chen FM, Hsieh MC, Huang TJ.Overexpression
of nitric oxide synthetase II in gastric mucosa
of rats with portal hypertension: Correlation
with gastric mucosal damage. J Surg Res
(Accepted in 2003)(SCI).
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38 |
Wang JY, Chang CT, Hsieh JS, Chen YF, Lee LW,
Huang TJ, Chai CY, Lin SR. Role of
MUC1 and MUC5AC expressions as prognostic
indicators in gastric carcinomas. J Surg Oncol
(Accepted in 2003)(SCI).
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39 |
Wang JY, Huang TJ, Chen FM, Hsieh MC, Lin
SR, Hou MF, Hsieh JS.(2003) Mutation
analysis of the putative tumor suppressor gene
PTEN/MMAC1 in advanced gastric carcinnomas.
Virchows Arch 442; 437~443(SCI).
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40 |
Ming-Chia Hsieh, Lin SR, Yuan-Chien
Yang, Hung-Chun Chen,Jiun-Nong Lin and Shyi-Jang
Shin.2002. Higher frequency of apolipoprotein E2
allele in type 2 diabetic patients with
nephropathy in Taiwan. J Nephrol
2002;15:368-373(SCI).
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41 |
Wu CH, Chen YF, Shin SJ, Lin SR.
2002 Mutant K-ras Oncogene Regulates
Steroidogenesis of Normal Human Adrenocortical
Cells by the RAF-MEK-MAPK Pathway..BJC 87:
1000-1005 (correspond)(SCI).
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42 |
Hsieh MC, Lin SR, Yang YC, Chen
HC, Lin JN, Shin SJ.2002.
Increased frequency of apolipoprotein E2 allele
in type 2 diabetic patients with nephropathy in
Taiwan.Journal of Nephrology 7: 277-280(SCI).
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43 |
Chong IW, Lin SR, Hwang JJ, Huang
MS, Wang TH, Hung JY , Paulauskis JD.
2002.Expression and regulation of macrophage
inflammatory protein - 1α gene by nicotine in
rat alveolar macrophages. Eur Cytokine Netw.
13(2); 242-9(SCI).
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44 |
Wang JY, Liana ST, Chena YF, Yanga YC,ChenbLT,
Lee KT, Tsung J, Huang TJ, Lin SR.2002.Unique
K-Ras Mutational Pattern In Pancreatic
Adenocarcinoma From Taiwanese Patients.Cancer
letters 180:153-158(correspond)(SCI).
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45 |
Wu CH, Lee SC, Chiu HH, Yang YC, Lian ST, Shin
SY, Lin SR. 2002, Morphological
change and elevation of cortisol secretion in
cultured human normal adrenocortical cells
caused by mutant p21K-ras protein. DNA Cell Biol
21(1) 21-29 (correspond)(SCI).
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46 |
Yu FJ, Wu DC, Kuo CH, Lu CY, Su YC, Lee YC,
Lin SR, Liu CS, Jan CM, Wang WM,
2001, Diagnosis of Helicobacter pylori infection
by stool antigen test in southern Taiwan,
Kaohsiung J Med Sci 17(7):344-50.
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47 |
Wu DC, Kuo CH, Lu CY, Su YC, Yu FJ, Lee YC,
Lin SR, Liu CS, Jan CM, Wang
WM,2001, Evaluation of an Office-based Urine
Test for Detecting Helicobacter Pylori: A
Prospective Pilot Study. Hepato-Gastroenterology
48:614-617(SCI)
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48 |
Huang TJ, Wang JY, Lin SR, Lian
ST, Hsieh JS, 2001, Overexpression of the c-met
Protooncogene in Human Gastric
Carcinoma--Correlation to Clinical Features.
Acta Oncologica 40: 638-643(SCI).
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49 |
Hsu CH, Lee SC, Yang YC, Lian ST, Shin SJ* and
Lin SR, 2001, The p53 codon 249
mutant - derived from human functional adrenal
tumors - can modify the cell shape of normal
adrenocortical transfected cells. Cancer Letters
170(1) 63-71(correspond)(SCI).
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50 |
Hsu CH, Yang YC, Lian ST, Lee SC, Shin SJ, and
Lin SR, 2001,. Significantly
increased cortisol secretion in normal
adrenocortical cells transfected with K-ras
mutants deriving from human functional
adrenocortical tumors. DNA & Cell Biol 20(4):
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51 |
Hsieh JS, Wang JY, Lin SR, Hsieh
TJ, Huang TJ. 2003.
Expression of Transforming Growth Factor α and
Epidermal Growth Factor Receptor mRNA in the
Gastric Mucosa of Portal Hypertensive Rats.
Hepatogastroenterology 50: 1305-1310(SCI).
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52 |
Wang JY, Lin SR, Hsieh JS, Hsu CH,
Huang YS and Huang TJ, 2001, Mutations of p53
gene in gastric carcinoma in Taiwan. Anticancer
Res 21: 513- 520(SCI).
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53 |
Hsieh MC, Lin SR, Hsieh TJ, Hsu
CH, Chen HC, Shin SJ, Tsai JH, 2001, Increased
frequency of angiotensin-converting enzyme DD
genotype. Nephrology Dialysis
Transplantation.15(7):1008-13.
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54 |
Wang JY, Hsieh JS, Lin SR , Huang
TJ, 2001, The effect of portal hypertension on
expression of gastric mucin mRNA in rats.
Hepato-Gastroenterology.48:667-671.
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55 |
Hsieh MC, Lin SR, Hsieh JS, Hsu
CH, Chen HC, Shin SJ, Tsai JH, 2000, Increased
frequency of angiotensin-converting enzyme DD
genotype in patients with type 2 diabetes in
Taiwan, Nephrology Dialysis Transplantation
15(7):1008-13.
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56 |
Hsieh TJ, Lin SR, Lee YJ, Shin SJ,
Lai YH, Hsu CH, Tsai JH. 2000, Increased renal
medullally endothelin-1 synthesis in
pre-hypertensive DOCA and salt treated rats. The
American Journal of Physiology 279:F112-F121.
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57 |
Chong IW, Lin SR, Hwang JJ, Huang
MS, Wang TH, Tsai MS, Hou JJ, and Paulauskis JD,
2000, Expression and regulation of macrophage
inflammatory protein-2 gene by vanadiumin mouse
macrophages. Inflammation 24(2):127-39.
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58 |
Lai FJ, Shin SJ, Lee YJ, Lin SR,
Jou WY and Tsai JH, 2000, Up-regulation of
adrenal cortical and medullary atrial
natriuretic peptide and gene expression in rates
with deoxycorticosterone acetate-salt treatment,
Endocrinol 141(1):325-332.
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59 |
Lin SR,
Hsu CH, Tsai JH, Wang JY, Hsieh TJ and Wu CH,
2000, Decreased GTPase activity of K-ras mutants
deriving from adrenocortical tumors. Br J
Cancer 82:1035-1040(correspond).
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60 |
Chen BH, Chiang CH, Lin SR, Chao
MG, Tsai S-T, 1999, The influence of Age at
Onset and Gender on the HLA-DQA1, DQB1
association in Chinese Chidren with inculin
dependent diabetes mellitus. Human Immunology.
60:1131-1137.
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61 |
Shin SJ, Lai FJ, Wen JD, Lin SR,
Hsieh MC, Hsiao PJ, Tsai JH, 1999, Increased
nitric oxide synthase mRNA expression in the
medulla of water-deprived rats. Kidney
International. 56:2191-2202.
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62 |
Shih MH, Sheu MM, Chen HY, Lin SR,
1999, Fungal keratitis caused by Candida utilis-case
report. Kaohsiung J Med Sci 15: 171-174.
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63 |
Lin CP, Tsai MC, Sun CY, Chen JY, Lin SR,
1999, Stability of self-prepared fortified
antibiotic eyedrops. Kaohsiung J Med Sci 15:
80-86.
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64 |
Wu DC, Wang WM, Lu CY, SU YC, Lin SR,
Liu CS, Jan CM, 1999, The hemodynamic changes of
gastroduodenal regional blood flow after
Helicobacter pylori eradication in patients with
duodenal ulcer scar. Kaohsiung J Med Sci
15:19-25.
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65 |
Hsu CH, Yang SA, Yu SY, Lin SR,
1999, Mutational spectrum of p53 gene in
arsenic-related skin cancers from the blackfoot
disease endemic area of Taiwan. BJC
80(7):1080-1086(correspond).
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66 |
Lin SR,
Yang YC, Tsai JH, Hsu CH, 1998, Alteration of
RET oncogene in human adrenal tumors. JPN J
Cancer Res 89(6): 634-640.
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67 |
Lin SR,
Tsai JH, Yang YC, Lee SC,1998,Mutations of K-ras
oncogene in human adrenal tumors in Taiwan, BJC
77(7): 1060-1065(correspond).
|
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68 |
Chen BH, Lin SR, Chiang CH and
Chao MC, 1998, Molecular characterization of
Chinese G6PD deficiency by using polymerase
chain reaction/single strand conformation
polymorphism. Kaohsiung J Med Sci 14:197-202.
|
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69 |
Chen KH, Sheu MM, Lin SR, 1997,
Rapid identification of Mycobacteria to the
species level by polymerase chain reaction and
restriction enzyme analysis-a case report of
corneal ulcer. Kaohsiung J Med Sci 13:583-588.
|
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70 |
Chong IW, Lin SR, Lin MS, Huang
MS, Tsai MS, Hwang JJ, 1997, Heparin-binding
epidermal growth factor and transforming growth
factor-a in human non-small cell lung cancers. J
Formos Med Assoc 96(8): 579-85.
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71 |
Lin SR,Yang
YC,Chang CH,Tsai JH,1996,A significant decrease
on the transcriptional activity of p53 mutants
deriving from human functional adrenal tumors,
DNA Cell Biol 15 (10):793-803(correspond).
|
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72 |
Jan CM, Wu DC, Su YC, Wang WM, Liu CS, Lin
SR, Chen CY, 1995, Evaluation of the
severity of Helicobacter pylori infection with
urease test: its corrrlation with histopathology
and bacterial density, Kaohsiung J Med Sci
11(12):650-3.
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73 |
Shin SJ,Lee YJ,Lin SR,Tan MS,Lai
YH,Tsai JH,1995,Decrease of renal endothelin-1
content and gene expression in diabetic rats
with moderate hyperglycemia, Nephron 70:486-493.
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74 |
Lee YJ,Shin SJ,Lin SR,Tan MS,Tsai
JH,1995,Increased expression of heparin
binding-epidermal growth factor like growth
factor mRNA in the kidney of strepto-zotocin
induced diabetic rats. Biochem Biophys Res
Commun 207:216-222.
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75 |
Lee YJ,Lin SR,Shin SJ,Lai YH,Lin
YT,Tsai JH,1994,Brain natriuretic peptide is
synthesized in the human adrenal medulla and its
messenger ribonucleic acid expression along with
that of atrial natriuretic peptide are enhanced
in patients with primary aldosteronism.J Clin
Endocrinol Metab 79(5):1476-1482.
|
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76 |
Wang WM,Chen CY,Jan CM,Chen LT,Peng DS,Lin
SR,Lin CS,1994,Long-term follow-up and
serological study after triple therapy of
Helicobacter pylori-associated duodenal ulcer.
AJG 89(10):1793-1796.
|
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77 |
Lin SR,Lee
YJ,Tsai JH,1994,Mutations of p53 gene in human
functional adrenal neoplasms.J Clin Endocrinol
Metab 78(2):483-491(correspond).
|
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78 |
Chang CY,Chang LL,Lin SR,Chang
SF,1993,Charaterization of R plasmid from
Shigella sonnei in Taiwan.Kaohsiung J Med Sci
9:616-624.
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79 |
Lee YJ,Lin SR,Tsai
JH,1993,Increased adrenal medullary atrial
natriuretic polypeptide synthesis in patients
with primary aldosteronism.J Clin Endocrinol
Metab 76(5):1357-1362.
|
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80 |
Juan KH,Lin SR,etc,1992,Bacterial
flora of the external ear canal-2.effect of
irradiation.Kaohsiung J Med Sci 8(1):21-23.
|
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81 |
Lin SR,etc,1992,Drug
resistance and plasmid profile in Taiwan.J
Epidemiol Infect 108:87-97(correspond).
|
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82 |
Juan KH,Lin SR,etc,1990,Bacterial
flora of the external ear canal-1.camcer
patients. Kaohsiung J Med Sci 6(8),418-421.
|
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83 |
Wang WM, Lin SR,etc,1990,
Evaluation of urease test, gram stain, culture
and histology in the detection.of Campylobacter
pylori.J Formosa Med Assoc 89(8):683-686.
|
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84 |
Yang SA, Lin SR,etc,1990,Pemphigus
foliaceus with cryptococcemia caused by
Cryptococcus albidus.Derm Sinica 8:31-35.
|
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85 |
Lin SR,etc,1989,Isolation
of Crytococcus albidus var.albidus in patient
with pemphigus foliaceus.Kaohsiung J Med
Sci.5(2):126-128.
|
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86 |
Lin SR,etc,1988,In
vitro antibacterial activity of
cefixime.Kaohsiung J Med Sci 4(10):586-591
|
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87 |
Lin SR,etc,1988,Molecular
characterization of virulence plasmid in
Shigella species.Kaohsiung J Med Sci
4(11):633-642
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88 |
Peng CF, Lin SR,1987,Serotypes and
antimicrobial susceptibility among clinical
isolates of Pseudomonas aeruginosa.Kaohsiung J
Med Sci 3(5) :309-317. |
|
89 |
Hsiao JY, Hsieh MC , Tien KJ, Hsu SC, Shin SJ,
Lin SR. 2007. A C/T Polymorphism
in the Exon 33 of the Thyroglobulin Gene Is
Associated with Relapse of Graves’
Hyperthyroidism after Antithyroid Withdrawal in
Taiwanese. J Clin Endo Metab
(in press)
(correspond) (SCI). I.F. 6.02
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國科會計畫︰
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計畫名稱 |
擔任工作 |
起迄年月 |
計畫編號 |
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人類嗜鉻細胞瘤及正常髓質組織心房利鈉胜
mRNA之研究 |
協同主持人 |
79.7-80.8 |
NSC-80-0412-B037-43 |
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幽門曲狀桿菌與十二指腸潰瘍再發之研究 |
協同主持人 |
80.2-81.1 |
NSC-80-0412-B037-55 |
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人類嗜鉻細胞瘤Endothelin-1之分子生物學及臨床研究 |
協同主持人 |
80.8-81.7 |
NSC-80-0412-B037-23 |
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表皮生長因子接受器及受器後反應與糖尿病大白鼠之腎臟肥大 |
協同主持人 |
80.8-81.7 |
NSC-80-0412-B037-24 |
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雷諾氏症侯群:Endothelin-1與PDGF之分子生物學及臨床研究 |
協同主持人 |
81.2-82.1 |
NSC-80-0412-B037- |
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肝素表皮結合生長因子傳訊核酸在大白鼠之腎臟間質細胞及STZ誘發糖尿病大白鼠之腎臟之研 |
協同主持人 |
81.8-82.7 |
NSC-80-0412-B037-011 |
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STZ誘發大白鼠糖尿病之尿液血管內皮素(ET-1)排泄量及腎臟ET-1
mRNA
之研究 |
協同主持人 |
81.8-82.7 |
NSC-80-0412-B037-019 |
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IgA腎炎病人之血中含IgA免疫複合體對腎絲球間質細胞外間質之影響 |
協同主持人 |
81.8-82.7 |
NSC-80-0412-B037-022 |
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人類腎上腺腫瘤p53基因異常情形之分析 |
主持人 |
82.2-83.1 |
NSC-80-0412-B037-091 |
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烏腳病患區皮膚癌患者之p53腫瘤抑制基因異常情形之分析 |
協同主持人 |
82.2-83.1 |
NSC-80-0412-B037-114 |
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人類腎上腺腫瘤G蛋白質致癌基因和ras致癌基因異常情形之分析 |
主持人 |
82.8-83.7 |
NSC-80-0412-B037-030 |
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人類功能性腎上腺腫瘤突變p53之轉錄活性分析 |
主持人 |
83.8-84.7 |
NSC-84-2331-B037-030 |
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生長因子之表皮生長因子接受器之傳訊者核醣核酸在人類非小細胞肺癌及正常肺組織之表現 |
共同主持人 |
83.8-84.7 |
NSC-84-2331-B037-024 |
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利用PCR/SSCP技術快速分析
G-6-PD
缺乏症之基因變異型 |
共同主持人 |
83.8-84.7 |
NSC-84-2331-B037-066 |
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人類功能性腎上腺腫瘤ret致癌基因之異常情形分析 |
主持人 |
84.8-85.7 |
NSC-85-2331-B037-017 |
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人類原發性皮質醛酮過多症突變p53特性及其對正常牛腎上腺皮質細胞所造成影響的研究
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主持人 |
85.8-86.7 |
NSC-86-2314-B037-069 |
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人類功能性腎上腺腫瘤突變K-RAS蛋白(p21)生化特性的研究 |
主持人 |
86.8-87.7 |
NSC-87-2314-B037-032 |
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門脈高壓對於老鼠胃黏液傳訊者核醣核酸表現量的影響 |
共同主持人 |
86.8-87.7 |
NSC-87-2314-B037-031 |
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晚期胃癌之p16與p53腫瘤抑制基因的變異情形 |
共同主持人 |
86.8-87.7 |
NSC-87-2314-B037-060 |
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原發性皮質醛酮過多症突變K-ras對正常牛腎上腺皮質細胞所造成影響的研究 |
主持人 |
87.8-88.7 |
NSC-88-2314-B037-049 |
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C-MET
原型致癌基因在人類晚期胃癌的表現 |
共同主持人 |
87.8-88.7 |
NSC-88-2314-B037-070 |
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門脈高壓對於老鼠胃黏膜轉形生長因子A與表皮生長受器核醣核酸表現量的影響 |
共同主持人 |
87.8-88.7 |
NSC-88-2314-B037-073 |
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功能性腎上腺腫瘤K-ras
誘發腎上腺皮質細胞類固醇賀蒙合成增加機制之研究 |
主持人 |
88.8-89.7 |
NSC-89-2314-B037-014 |
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以差異性基因表現法分析晚期胃癌及轉移性胃癌相關致病基因之研究 |
共同主持人 |
88.8-89.7 |
NSC-89-2314-B037-068 |
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可誘發性一氧化氮合成?在門脈高壓鼠的調節功能:與胃黏膜上皮細胞增生能力及胃黏液素含量潛在相關分析 |
共同主持人 |
88.8-89.7 |
NSC-89-2314-B037-067 |
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原發性皮質醛酮過多症突變K-ras促進正常腎上腺皮質細胞類固醇賀爾蒙合成增加機轉系列研究(1/2) |
主持人 |
89.8-90.7 |
NSC-89-2314-B037-152 |
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黏液素MUC1與MUC5A/C的表現與胃癌轉移的相關性 |
共同主持人 |
89.8-90.7 |
NSC-89-2314-B037-131 |
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可誘發性一氧化氮合成?在門脈高壓鼠的調節功能：與胃黏膜上皮細胞增生能力及胃黏液素含量潛在相關分析(2/2) |
共同主持人 |
89.8-90.7 |
NSC-89-2314-B037-159 |
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分析進行期胃癌的PTEN/MMAC1基因變異情形 |
共同主持人 |
89.8-90.7 |
NSC-89-2314-B037-120 |
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以老鼠模式探討在尼古丁引起肺部發炎反應中巨嗜細胞蛋白-2基因表現及調節 |
共同主持人 |
89.8-90.7 |
NSC-89-2314-B037-130 |
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原發性皮質醛酮過多症突變K-ras促進正常腎上腺皮質細胞類固醇賀爾蒙合成增加機轉系列研究(2/2)
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主持人
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90.8-91.7
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NSC-90-2314-B037-033
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以抑制性刪減雜交法分析胃癌轉移性因子的研究
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共同主持人
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90.8-91.7
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NSC-90-2314-B037-074
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以抑制性刪減雜交法(SSH)探討由大腸增生性息肉至大腸癌致癌過程中所參與因子的研究
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主持人
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90.8-91.7
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NSC-90-2314-B037-075
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人類胃腺癌突變P53知轉錄活性分析與細胞凋亡系列研究
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共同主持人
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90.8-91.7
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NSC-90-2314-B037-082
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門脈高壓胃黏膜之細胞凋亡情形
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共同主持人
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90.8-91.7
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NSC-90-2314-B037-091
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以突變K-ras穩定轉染之細胞珠探討K-ras參與固醇賀爾蒙生合成之分子機轉及抑制cortisol過度分泌之新藥研發的細胞模式(1/2) |
主持人 |
91.8-92.7 |
NSC91-2314-B-037-324 |
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分子技術偵測胃癌病患術中腹腔沖洗液內之游離癌細胞 |
共同主持人 |
91.8-92.7 |
NSC91-2314-B-037-281 |
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以分子標記作為胃癌病患術後追蹤之標的 |
共同主持人 |
91.8-92.7 |
NSC91-2314-B-037-317 |
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抽菸引起慢性組塞性肺疾病患者的診斷及治療分子標記的開發與研究 |
共同主持人 |
91.8-92.7 |
NSC91-2314-B-037-293 |
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急性腸系膜缺血與血漿中一氧化氮及內皮細胞素-1濃度關聯性的探討 |
共同主持人 |
91.8-92.7 |
NSC91-2314-B-037-285 |
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以突變K-RAS轉染之細胞探討K-RAS參與Steoidogenesis之分子機制及抑制cortisol過度分泌之新藥研發的細胞模式 |
主持人 |
92.8-93.7 |
NSC 92-2314-B-037-054 |
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抽煙引起慢性組塞性肺疾病患者的診斷及治療分子標記的開發與研究 |
共同主持人 |
92.8-93.7 |
NSC 92-2314-B-037-011 |
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分子偵測胃癌病患週邊血液之cytokeratin-19與Htert傳訊者核糖核酸作為循環生物標記 |
共同主持人 |
92.8-93.7 |
NSC 92-2314-B-037-095 |
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乳癌分子診斷標記之鑑定暨癌化過程所差異表現基因之確認 |
共同主持人 |
92.8-93.7 |
NSC 92-2314-B-037-091 |
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以腫瘤分子標記作為大腸直腸癌病患術後追蹤之標的 |
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